OP0210-HPR THE OCCURRENCE OF OVERWHELMING FATIGUE IN INDIVIDUALS WITH KNEE OSTEOARTHRITIS: A DAILY DIARY STUDY

Background Cross sectional research shows that nearly half of the individuals with osteoarthritis (OA) experience fatigue and over one third severe (1). However, few studies have addressed unpredictable fluctuating course in OA including occurrence overwhelming as evidenced from qualitative (2). In-depth understanding its determinants may inform clinical decision making treatment. Objectives To explore 1) 2) variability daily experienced knee OA. Methods A diary design. 73 participants a self-reported diagnosis aged >40 years possession Smartphone completed baseline questionnaire on demographics, health status (EQ5D-VAS), self-efficacy (Arthritis Self-Efficacy Scale (ASES)). This was followed by assessments regard to fatigue, severity, pain, sleep, perceived exertion physical activities (PEPA) 7 day period. yes/no format used assess numeric rating scale (NRS, 0-10) PEPA. The assessed calculating standard deviation (SD) per participant this Comparisons between without were conducted unpaired t-tests Pearson’s chi-square tests where appropriate. Results 47 included analysis. Overwhelming occurred at least once 26 (55%) mean= 2.7 (SD= 1.4) Differences are displayed Table 1. Characteristics (n=47) Characteristics* All (n=47 ) Participants (n=26 (n=21 Difference (95% CI p-value Age 63.4 (8.6) 61.7 (8.5) 65.5 -3.8 (-8.8; 1.2) 0.13 Female (n (%)) 39 (83%) 23 (88%) 16 (76%) 0.47 BMI 27.4 (4.6) 28.0 (5.1) 26.5 (3.8) 1.5 (-1.1; 4.1) 0.25 Health 67.5 (13.8) 66.0 (13.5) 69.5 (14.2) -3.5 (-11.7; 4.7) 0.39 ASES pain 2.9 (1.0) 3.2 (0.8) 2.5 (1.1) 0.7 (0.1; 1.3) 0.02 os 2.2 (0.7) 0.5 1.0) Fatigue severity 4.9 (1.7) 5.5 (1.5) 4.1 (1.6) 1.3 (0.4; 2.3) 0.01 Pain 4.2 (1.9) 4.8 3.4 (2.0) 1.4 (0.3; 2.5) Sleep 5.9 6.4 (1.4) -0.9 (-1.8; -0.0) 0.05 PEPA (1.2) 5.0 (1.3) 0.2 (-0.6; 0.9) 0.64 ASES, Arthritis Scale; os, other symptoms; PEPA, activities. For status, higher scores reflect better outcomes; for more PEPA; levels. *mean unless otherwise statedg. ranged SD= (Figure 1). not significantly different fatigue. Figure Standard deviations average period (n=47). Conclusion Our findings suggest than episode is related self-efficacy, sleep. remained fairly stable time majority participants. References [1]Overman CL, Kool MB, da Silva JAP, Geenen R. prevalence rheumatic diseases: an international study. Clin Rheumatol. 2016;35:409–15. [2]Power JD, Badley EM, French MR, Wall AJ, Hawker GA. osteoarthritis: BMC Musculoskeletal Disorders. 2008;9:63. Acknowledgements We would like thank Yvonne Peters her involvement study design data collection. Disclosure Interests None declared